I’m partially working from home.
The interactions and office chat I would probably miss too, had it been that I only worked from home.
The major disadvantage, however, is that it is sometimes bloody hard to get things done. It’s VERY tempting to think "yeah I’m gonna get started with that right after I’ve read the news… or right after I’ve done the dishes (in those unfortunate cases when doing dishes seems more tempting than to actually do a work task you are paid to do)… and before you know it it’s evening and you realise that it may be a good idea to go out and get some fresh air after staying inside all day…